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Thionyl Chloride → 4-Oxo-3-thiazolidinylacetyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-(4-Oxo-1,3-thiazolidin-3-yl)acetic acid | HCID 5147257 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Oxo-3-thiazolidinylacetyl chloride | HCID 21297225 | — |
反応手順
Thionyl chloride (2.00 ml) was added dropwise to a solution of 4-oxo-3-thiazolidinylacetic acid (1.60 g) in a mixture of dichloromethane (20 ml) and tetrahydrofuran (5.0 ml) at room temperature. After the mixture was stirred for 5 hours at the same temperature, the solvent was evaporated in vacuo to give 4-oxo-3-thiazolidinylacetyl chloride (1.78 g) as brown semisolid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764514 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-566cc7d4e2bc48d4b9bbc4f953cfff39 |
| 出典メモ | uspto-grants-1988_08 |