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2,6-Dimethylaniline → N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dimethylaniline | HCID 6896 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 2-(4-Oxo-3-thiazolidinyl)propionic acid | HCID 23245350 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide | HCID 13853984 | 45.7% |
反応手順
A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764514 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-6a9aab5ee7f74d7c9c9deececbc2446a |
| 出典メモ | uspto-grants-1988_08 |