Naphthalen-1(2H)-one → 1-Tetralol, (S)-

HRID 349153ノート

反応式

HRID 349153 の反応式
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH2:2]1>O>[C@@H:1]1([OH:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 12446728Naphthalen-1(2H)-one

生成物 1

HCID 70580291-Tetralol, (S)-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Washed phaseolus aureus L (green grams) 50 g. were taken into a conical flask and allowed to soak in deionised water (400 ml) for a period of 24 hr. 1-naphthalenone (0.500 g; 0.0034 moles) III was added to the soaked phaseolus aureus L (green grams) in the above water, covered and allowed to shake for 46 hr at 15–20° C. Then the green grams were filtered off and washed with deionised water (3×100 ml). The combined filtrate was extracted with chloroform (3×500 ml). The chloroform layer was dried and the crude product obtained (480 mg). Pure (1S)-1,2,3,4-tetrahydro-1-naphthalenol (IV) was obtained after column chromatography with silica gel using chloroform as eluent.

後処理

  1. washWashed phaseolus aureus L (green grams) 50 g
  2. customwere taken into a conical flask
  3. waitto shake for 46 hr at 15–20° C
  4. filtrationThen the green grams were filtered off
  5. washwashed with deionised water (3×100 ml)
  6. extractionThe combined filtrate was extracted with chloroform (3×500 ml)
  7. dry with materialThe chloroform layer was dried
  8. customthe crude product obtained (480 mg)

出典と根拠

ORDレコード
ord-2fee8231d3e649eca9153298ded26cc4
出典データセット
uspto-grants-2007_02
特許番号
US07179624B2

反応ノート

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