化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetoacetate → 3-Allyl-6-methyluracil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | Allylurea | HCID 11181 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 触媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Allyl-6-methyluracil | HCID 13602047 | — |
反応手順
To allylurea (25 g, 0.25 mol) in ethanol (10 mL) was added ethyl acetoacetate (31.86 mL, 0.25 mol) and 10 drops conc. HCl. After 12 days at room temperature, concentration gave an oil which was dissolved in MeOH. KOH (22.5 g, 0.34 mol) was added and the solution refluxed for 1 hour. After neutralization, the resulting solid 1 was collected. Yield 2.7 g (7%). NMR (CDCl3) δ: 2.16 (3H, s), 4.52 (2H, d), 5.18 (1H, d), 5.23 (1H, d), 5.60 (1H, s), 5.82–5.93 (1H, m), 10.3 (1H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07179815B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-07db849e044840039386e1356153d402 |
| 出典メモ | uspto-grants-2007_02 |