Hydrochloric Acid → N-(2-aminoethyl)-pyridine-2-carboxamide dihydrochloride
反応式
[NH:1]([CH2:5][CH2:6][NH:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)=[O:9])C(C)=O.[ClH:16]>>[ClH:16].[ClH:16].[NH2:1][CH2:5][CH2:6][NH:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)=[O:9]参加物
3
実験手順
12.0 g of N-(2-acetaminoethyl)-2-pyridine- carboxamide were suspended in 100 ml of alcohol and 116 ml of 2N hydrochloric acid and the suspension was heated to reflux overnight. The reaction mixture was thereafter concentrated under reduced pressure, the solid residue (13.4 g) was boiled up with methanol, cooled, suction filtered and dried. There was obtained N-(2-aminoethyl)-pyridine-2-carboxamide dihydrochloride as white crystals, m.p. 262° (dec.).
後処理
- temperatureto reflux overnight
- concentrationThe reaction mixture was thereafter concentrated under reduced pressure
- temperaturecooled
- filtrationsuction filtered
- customdried
出典と根拠
- ORDレコード
- ord-db2823222c1e4d8188026bb193d9765e
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04764522
反応ノート
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