(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid → Ethyl(2s)-2-[(4s)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate

HRID 349411ノート

反応式

HRID 349411 の反応式
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([OH:15])=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].N1([S:21](Cl)=[O:22])C=CN=C1>ClCCl>[CH3:12][C@H:11]1[C:13](=[O:15])[O:14][S:21](=[O:22])[N:10]1[C@@H:4]([CH2:3][CH2:2][CH3:1])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

4

反応物 2

HCID 10015159(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acidHCID 113325591H-Imidazole-1-sulfinyl chloride

生成物 1

HCID 11242493Ethyl(2s)-2-[(4s)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Introduce into a reactor 200 g of N-[(S)-ethoxycarbonyl-1-butyl]-(S)-alanine and 1.5 liters of dichloromethane and then, at 0° C., add 325 g of 1H-imidazole-1-sulphinyl chloride. Subsequently, bring the reaction mixture to ambient temperature and then, after stirring for 1 hour, filter off the precipitate formed. The filtrate obtained is evaporated to dryness to yield the expected product in the form of an oil.

後処理

  1. customto ambient temperature
  2. filtrationfilter off the precipitate
  3. customformed
  4. customThe filtrate obtained
  5. customis evaporated to dryness

出典と根拠

ORDレコード
ord-8480382943764e6d9946aa05c1ece591
出典データセット
uspto-grants-2007_02
特許番号
US07179833B2

反応ノート

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