HCID 22139808、化合物 → methyl 3-amino-4-chlorothiophene-2-carboxylate
反応式
C([NH:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12])(=O)C>CO.Cl>[NH2:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12]参加物
4
実験手順
was obtained by stirring a solution of 7 g of methyl 3-acetylamino-4-chlorothiophene-2-carboxylate in a mixture of 50 ml of methanol and 50 ml of concentrated hydrochloric acid at 60° C. for 4 hours and at room temperature for 2 days. The mixture was filtered, the solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water were added and the crystals were filtered off after stirring at room temperature. Crystalline product. M.p. 62–64° C.
後処理
- customwas obtained
- filtrationThe mixture was filtered
- distillationthe solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water
- additionwere added
- filtrationthe crystals were filtered off
出典と根拠
- ORDレコード
- ord-7f266a2370f04a3e9cd7fc83367554db
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07179830B2
反応ノート
読み込み中…