Cesium carbonate → {4-[5-(3-Bromophenyl) tetrazol-2-ylmethyl]benzyl}phosphonic acid dimethyl ester

HRID 349455

反応式

HRID 349455 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[N:10][NH:11][N:12]=2)[CH:5]=[CH:6][CH:7]=1.[C:13](=O)([O-])[O-].[Cs+].[Cs+].[CH3:19][O:20][P:21]([CH:25](C)[C:26]1[CH:31]=[CH:30][C:29](Br)=[CH:28][CH:27]=1)(=[O:24])[O:22][CH3:23]>CN(C=O)C.C(OCC)(=O)C>[CH3:23][O:22][P:21]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([CH2:13][N:10]2[N:11]=[N:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)=[N:9]2)=[CH:30][CH:31]=1)(=[O:24])[O:20][CH3:19]

参加物

6

反応物 3

HCID 10796Cesium carbonateHCID 40730565-(3-bromophenyl)-1H-1,2,3,4-tetrazoleHCID 86626606HCID 86626606、化合物

生成物 1

HCID 86626605{4-[5-(3-Bromophenyl) tetrazol-2-ylmethyl]benzyl}phosphonic acid dimethyl ester

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 5-(3-bromophenyl)-2H-tetrazole (0.5 g, 2.22 mmol) in DMF (15 mL) was added cesium carbonate (0.94 g, 2.89) and the mixture stirred at room temperature for 15 minutes. To this was added (4-bromo-methylbenzyl) phosphonic acid dimethyl ester (0.85 g, 3.05 mmol) and the reaction mixture stirred over night at room temperature. The reaction mixture was diluted with ethyl acetate, washed with water, brine, dried over MgSO4, filtered, and the evaporated to dryness.

後処理

  1. stirringthe reaction mixture stirred over night at room temperature
  2. washwashed with water, brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe evaporated to dryness

出典と根拠

ORDレコード
ord-c479c7576f7a455e905f468b16856b1b
出典データセット
uspto-grants-2007_02
特許番号
US07179822B2

関連ノート

読み込み中…