N-(2-aminoethyl)acetamide → N-{2-[(5-bromofuran-2-yl)formamido]ethyl}acetamide

HRID 34946

反応式

HRID 34946 の反応式
[Br:1][C:2]1[O:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[C:10]([NH:13][CH2:14][CH2:15][NH2:16])(=[O:12])[CH3:11]>C(Cl)Cl.C(N(CC)CC)C>[NH:13]([CH2:14][CH2:15][NH:16][C:7]([C:5]1[O:6][C:2]([Br:1])=[CH:3][CH:4]=1)=[O:8])[C:10]([CH3:11])=[O:12]

参加物

5

反応物 2

HCID 66082N-(2-aminoethyl)acetamideHCID 27570115-Bromofuran-2-carbonyl chloride

生成物 1

HCID 13800218N-{2-[(5-bromofuran-2-yl)formamido]ethyl}acetamide

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒2 回HCID 8471Triethylamine溶媒

実験手順

A solution of 22.6 g of 5-bromo-2-furancarboxylic acid chloride in 100 ml of methylene chloride was added dropwise within 20 minutes at 0°-8° to a solution, pre-cooled to 0°, of 11.0 g of monoacetyl-ethylenediamine in 250 ml of methylene chloride and 18 ml of triethylamine. The reaction mixture was stirred at room temperature overnight, suction filtered and washed with methylene chloride. There was obtained N-(2-acetamino ethyl)-5-bromo-2-furancarboxamide as pale beige crystals, m.p. 175°-176°.

後処理

  1. filtrationsuction filtered
  2. washwashed with methylene chloride

出典と根拠

ORDレコード
ord-06adfa65536a4672ba2c77c29a74e2ea
出典データセット
uspto-grants-1988_08
特許番号
US04764522

関連ノート

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