Hydrochloric Acid → 5-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride

HRID 34947ノート

反応式

HRID 34947 の反応式
[NH:1]([CH2:5][CH2:6][NH:7][C:8]([C:10]1[S:11][C:12]([Br:15])=[CH:13][CH:14]=1)=[O:9])C(C)=O.[ClH:16]>>[ClH:16].[Br:15][C:12]1[S:11][C:10]([C:8]([NH:7][CH2:6][CH2:5][NH2:1])=[O:9])=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 2604169N-(2-acetamidoethyl)-5-bromothiophene-2-carboxamide

生成物 1

HCID 138002765-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride

実験手順

N-(2-Acetaminoethyl)-5-bromo-2-thiophenecarboxamide was reacted with hydrochloric acid in an analogous manner to that described in Example 1, paragraph 3. The residue was dissolved in alcohol (pH 1), filtered and concentrated to about 300 ml under reduced pressure. After cooling to 5° the product was filtered off under suction and dried, whereby 5-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride was obtained as white crystals, m.p. 221°-222°, after recrystallization from ethanol.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated to about 300 ml under reduced pressure
  3. temperatureAfter cooling to 5° the product
  4. filtrationwas filtered off under suction
  5. customdried

出典と根拠

ORDレコード
ord-54ae05bc05c541b0a898ca7dc86540e6
出典データセット
uspto-grants-1988_08
特許番号
US04764522

反応ノート

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