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Picolinic acid → Pyridine-2-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Picolinic acid | HCID 1018 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Pyridine-2-carbonyl chloride | HCID 135034 | — |
反応手順
10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764522 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-0c9b8f17431e45df938f2c9f0e1931bb |
| 出典メモ | uspto-grants-1988_08 |