Picolinic acid → Pyridine-2-carbonyl chloride

HRID 34949

反応式

HRID 34949 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.S(Cl)([Cl:12])=O>C1(C)C=CC=CC=1.CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:12])=[O:9]

参加物

5

反応物 2

HCID 1018Picolinic acidHCID 24386Thionyl Chloride

生成物 1

HCID 135034Pyridine-2-carbonyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 1140Toluene溶媒

実験手順

10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.

後処理

  1. temperaturethe suspension was heated
  2. customThereafter, the mixture was evaporated to dryness under reduced pressure
  3. additionthe residue was treated with toluene
  4. customagain evaporated to dryness

出典と根拠

ORDレコード
ord-0c9b8f17431e45df938f2c9f0e1931bb
出典データセット
uspto-grants-1988_08
特許番号
US04764522

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