Hydrochloric Acid → HCID 69131552、化合物

HRID 349498ノート

反応式

HRID 349498 の反応式
C[O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[C:16]([Cl:21])[CH:15]=3)[NH:10][C:9]=2[C:8]([O:22]C)=[CH:7][CH:6]=1)=[O:4].[Cl-].[Al+3].[Cl-].[Cl-].Cl>C1(C)C=CC=CC=1>[Cl:21][C:16]1[CH:15]=[C:14]([C:11]2[NH:10][C:9]3[C:8]([OH:22])=[CH:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[C:13]=3[N:12]=2)[CH:19]=[CH:18][C:17]=1[F:20]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 691319642-(3-chloro-4-fluoro-phenyl)-7-methoxy-1H-benzoimidazole-4-carboxylic acid methyl ester

生成物 1

HCID 69131552HCID 69131552、化合物収率 80%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2-(3-chloro-4-fluoro-phenyl)-7-methoxy-1H-benzoimidazole-4-carboxylic acid methyl ester (0.95 g, 8.98 mmol) obtained in step 2 was dissolved in toluene, aluminum chloride (1.5 g, 11.25 mmol) was added thereto and refluxed for 8 hours. The resulting solution was cooled to room temperature, the reaction was stopped by adding 3 N HCl thereto and stirred for 30 min. The precipitate formed was filtered, washed with benzene and dried to obtain the title compound (0.81 g, 2.64 mmol) in a yield of 80%.

後処理

  1. temperaturerefluxed for 8 hours
  2. customThe precipitate formed
  3. filtrationwas filtered
  4. washwashed with benzene
  5. customdried

出典と根拠

ORDレコード
ord-78a71f529ad6403b953db0d832d6fd73
出典データセット
uspto-grants-2007_02
特許番号
US07179832B2

反応ノート

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