Hydrochloric Acid → 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde
反応式
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][C:3]=1[C:10]#N.Cl.C[OH:14]>[C].[Pd]>[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][C:3]=1[CH:10]=[O:14]参加物
5
実験手順
To a solution of 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carbonitrile (15 g) in methanol (300 ml) was added hydrochloric acid (1.8 ml) under ice-cooling. The resulting solution was stirred for 15 minutes. The mixture was treated with 10% palladium carbon (7.5 g) under a hydrogen atmosphere at room temperature for 3 hours. After the catalyst was filtered off, the filtrate was concentrated in vacuo to give 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde (13.3 g).
後処理
- temperaturecooling
- filtrationAfter the catalyst was filtered off
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-67e106826f9c4d3fac004ef6ef0484cf
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07179801B2
反応ノート
読み込み中…