Ethyl formate → 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

HRID 349571ノート

反応式

HRID 349571 の反応式
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.[CH:12](OCC)=[O:13]>>[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH:11][CH:12]=[O:13])[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 8025Ethyl formateHCID 1357327622-(2,3-Dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethanamine

生成物 1

HCID 1363341052-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

実験手順

A suspension of 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylamine (155 mg) in ethyl formate (3 ml) was refluxed for 4.5 hours. After evaporation of the solvent in vacuo, the residue was triturated with ethyl acetate and dried in vacuo to give 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide (165 mg) as a solid.

後処理

  1. temperaturewas refluxed for 4.5 hours
  2. customAfter evaporation of the solvent in vacuo
  3. customthe residue was triturated with ethyl acetate
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-20db1619b3a544cd8dc99178597891e5
出典データセット
uspto-grants-2007_02
特許番号
US07179801B2

反応ノート

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