関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| 反応物 | N-(2-Methoxyphenyl)piperazine hydrochloride | HCID 9899402 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 10268333 | HCID 10268333 | — |
反応手順
A mixture of 5-chloro-2-nitrophenylamine (1.3 g, 7.0 mmol), 1-(2-methoxyphenyl)-piperazine hydrochloride (5.0 g, 20 mmol), and K2CO3 (4.0 g, 29 mmol) in DMF (20 mL) was stirred at 110° C. for 18 h. The reaction mixture was cooled to room temperature and poured into water (200 mL). The crude solid product was collected by filtration, air dried, and purified by trituration with CHCl3 (1.3 g, 57%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07179912B2 |
|---|
| 出典データセット | uspto-grants-2007_02 |
|---|
| ORD ID | ord-579e613bfeb34d5e8b55a1c38dc40bb2 |
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| 出典メモ | uspto-grants-2007_02 |
|---|
