Sodium Cyanide → 5-(2-Propyl-3,4-dichlorophenoxy)pentane nitrile
反応式
[CH2:1]([C:4]1[C:16]([Cl:17])=[C:15]([Cl:18])[CH:14]=[CH:13][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]Br)[CH2:2][CH3:3].[C-]#[N:20].[Na+]>CN(C)C=O>[CH2:1]([C:4]1[C:16]([Cl:17])=[C:15]([Cl:18])[CH:14]=[CH:13][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:20])[CH2:2][CH3:3]参加物
4
実験手順
A solution of 1.6 g. of 5-(2-propyl-3,4dichlorophenoxy)pentyl bromide and 0.22 g. of sodium cyanide were heated overnight at 75°-85° C. in 50 ml. of dimethylformamide. The solution was evaporated in vacuo and ethyl acetate and water were added to the residue. The layers were separated and the organic layer was washed several times with a saturated sodium chloride solution. The organic solution was filtered through sodium sulfate and evaporated to dryness to give 1.38 g. of the desired sub-title intermediate. NMR.