2-Methoxy-5-nitroaniline → HCID 11668152、化合物

HRID 349729

反応式

HRID 349729 の反応式
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:4]=1[NH2:5].[Cl:13][C:14]1[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:15]=1[C:16]([N:18]=[C:19]=[O:20])=[O:17]>CN1CCCC1=O>[Cl:13][C:14]1[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:15]=1[C:16]([NH:18][C:19]([NH:5][C:4]1[CH:6]=[C:7]([N+:10]([O-:12])=[O:11])[CH:8]=[CH:9][C:3]=1[O:2][CH3:1])=[O:20])=[O:17]

参加物

4

反応物 2

HCID 74472-Methoxy-5-nitroanilineHCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

生成物 1

HCID 11668152HCID 11668152、化合物収率 96.7%

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

1 g (5.9 mmol) of 2-methoxy-5-nitroaniline were admixed with 1.3 g (5.9 mmol) of 2-chloro-4,5-difluorobenzoyl isocyanate from stage a in 2 ml of N-methylpyrrolidone and reacted at room temperature for one hour. The precipitate was filtered off, washed twice with 5 ml of acetonitrile each time and dried under high vacuum. 2.2 g of the desired product were obtained which were used in stage c without further purification.

後処理

  1. customreacted at room temperature for one hour
  2. filtrationThe precipitate was filtered off
  3. washwashed twice with 5 ml of acetonitrile each time
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-3f8c8a6abb5a41e6a0cce92ad6ed6b7d
出典データセット
uspto-grants-2007_02
特許番号
US07179941B2

関連ノート

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