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Phenol → 6-(2-Pentyl-3,4-dichlorophenoxy)hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | 6-Bromohexanoic acid | HCID 20210 | — |
| 反応物 | Propyltriphenylphosphonium bromide | HCID 80374 | — |
| 反応物 | 2-Pentyl-3,4-dichlorophenol | HCID 21297280 | — |
| 反応物 | 2,3-Dihydro-2-hydroxy-4,5-dichlorobenzofuran | HCID 21297295 | — |
| 反応物 | 2-(2-Pentenyl)-3,4-dichlorophenol | HCID 54411610 | — |
| 生成物 | 6-(2-Pentyl-3,4-dichlorophenoxy)hexanoic acid | HCID 21297306 | — |
反応手順
Following the general procedure of Example 6B, 2.3 g. of 2,3-dihydro-2-hydroxy-4,5-dichlorobenzofuran and 17.3 g. of propyltriphenylphosphonium bromide were reacted to provide 840 mg. of 2-(2-pentenyl)-3,4-dichlorophenol which upon hydrogenation following the procedure of Example 6C provided 300 mg. of 2-pentyl-3,4-dichlorophenol. This phenol was then reacted with 5.1 mmoles of 6-bromohexanoic acid following the procedure of Example 1C to provide 58 mg. of the desired title product. NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764521 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-bcfad02dc81843998440c27ff8dbbb80 |
| 出典メモ | uspto-grants-1988_08 |