5-Bromopentanenitrile → HCID 178439672、化合物

HRID 34976

反応式

HRID 34976 の反応式
[CH2:1]([C:4]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:5]=1[OH:6])[CH2:2][CH3:3].Br[CH2:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18].[N-:19]=[N+:20]=[N-:21].CN(C)C(=[NH2+])N(C)C>CN(C)C=O>[CH2:1]([C:4]1[C:5]([OH:6])=[CH:7][CH:8]=[CH:9][C:10]=1[O:11][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[NH:18][N:21]=[N:20][N:19]=1)[CH2:2][CH3:3]

参加物

5

反応物 3

HCID 794355-BromopentanenitrileHCID 2620601,3-Benzenediol, propyl-HCID 178484365HCID 178484365、化合物

生成物 1

HCID 178439672HCID 178439672、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Six grams of 2-propylresorcinol and 6.4 g. of 5-bromovaleronitrile were reacted following cedure of Example 2A to provide 3.4 g. of the desired nitrile intermediate. This intermediate was heated to 125° C. overnight with 40 mmoles of tetramethylguanidinium azide in 10 ml. of dimethylformamide. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate. The organic solution was washed with water adjusted to pH 6. The organic layer was dried and evaporated to yield the desired subtitle tetrazole intermediate which crystallized after evaporation of the solvent. NMR.

後処理

  1. customto provide 3.4 g
  2. customThe solvent was removed under reduced pressure
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washThe organic solution was washed with water
  5. customThe organic layer was dried
  6. customevaporated

出典と根拠

ORDレコード
ord-06cd2fb2963b4f3c9f8a55e07e3e2ef8
出典データセット
uspto-grants-1988_08
特許番号
US04764521

関連ノート

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