化工社化工社 化学情報印刷レポート · 研究参考用
Atropic acid → 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Atropic acid | HCID 68114 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid | HCID 45588421 | 54.3% |
反応手順
Piperazine-1-carboxylic acid tert-butyl ester (17.43 g) and 2-phenylacrylic acid (18 g) in iso-propanol (500 ml) was heated at reflux for four days. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give the title compound as a white solid (17 g; MS: APCI+(M+H) 335).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07179922B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-908250ec0eec43b19824e226329ee85a |
| 出典メモ | uspto-grants-2007_02 |