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Acetic Acid → 5-Methanesulfonyl-1H-indole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate | HCID 735868 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Methanesulfonyl-1H-indole-2-carboxylic acid | HCID 22394446 | 23.8% |
反応手順
To a solution of the 5-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester (0.49 g) in THF (12 mL) and water (4 ml) was added LiOH (0.098 g). The reaction mixture was left to stir for 2 hours. Acetic acid was added and the product extracted with dichloromethane. The organic extracts were combined, dried with magnesium sulfate, filtered and the filtrate evaporated to give the title compound as a solid (0.110 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07179922B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-59bd6241b13b4cf58ff933b7a25a70c8 |
| 出典メモ | uspto-grants-2007_02 |