Hydrochloric Acid → 2-(1-Benzyl-5-phenyl-1H-pyrazol-4-YL)acetic acid

HRID 349929ノート

反応式

HRID 349929 の反応式
[CH2:1]([N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11](CC#N)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:22].[K+].Cl.[CH2:25]([OH:27])[CH3:26]>>[CH2:1]([N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11]([CH2:26][C:25]([OH:22])=[O:27])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 23024861(1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetonitrile

生成物 1

HCID 230247242-(1-Benzyl-5-phenyl-1H-pyrazol-4-YL)acetic acid収率 99%

実験手順

A mixture of (1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetonitrile (3.50 g), a 4N aqueous potassium hydroxide solution (16 ml), and ethanol (50 ml) was refluxed for 4 hours. The reaction mixture was acidified with 1N hydrochloric acid, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated to obtain (1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetic acid (3.70 g, yield: 99%) as a colorless oily substance.

後処理

  1. extractionwas extracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with saturated aqueous sodium chloride solution
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-a9d90f6648744fa5a87a01702b35a9bc
出典データセット
uspto-grants-2007_02
特許番号
US07179823B1

反応ノート

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