Formic Acid → HCID 178470745、化合物

HRID 349931ノート

反応式

HRID 349931 の反応式
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:7]=[N:8][N:9](CC2C=CC=CC=2)[C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:2].C(O)=O>[C].[Pd].C(O)C>[C:11]1([C:10]2[C:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:24])=[CH:7][NH:8][N:9]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 2

HCID 284Formic AcidHCID 70122986ethyl(1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetate

生成物 1

HCID 178470745HCID 178470745、化合物収率 90.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

A mixture of ethyl(1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetate (3.60 g), 5% palladium-carbon (7.00 g), formic acid (40 ml), and ethanol (150 ml) was refluxed for 2 hours. After the palladium-carbon was removed by filtration, the filtrate was concentrated. The residue was dissolved in ethyl acetate, washed with saturated aqueous sodium bicarbonate and then with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated to obtain ethyl (3-phenyl-1H-pyrazol-4-yl)acetate (2.33 g, yield: 90%) as a colorless oily substance.

後処理

  1. temperaturewas refluxed for 2 hours
  2. customAfter the palladium-carbon was removed by filtration
  3. concentrationthe filtrate was concentrated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwashed with saturated aqueous sodium bicarbonate
  6. dry with materialwith saturated aqueous sodium chloride solution, dried (MgSO4)
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-6fdc3d33afd94580baedd7746148744e
出典データセット
uspto-grants-2007_02
特許番号
US07179823B1

反応ノート

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