1-[3-Amino-3-(4-methylphenyl)propyl]piperidine → N-[1-(4-methylphenyl)-3-piperidinopropyl]quinaldinamide
反応式
[NH2:1][CH:2]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[N:18]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:19]=1[CH2:20][C:21](Cl)=[O:22]>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([CH:2]([NH:1][C:21]([CH2:20][C:19]2[CH:24]=[CH:25][C:26]3[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:18]=2)=[O:22])[CH2:3][CH2:4][N:5]2[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]2)=[CH:12][CH:13]=1参加物
3
実験手順
The procedure of Example 1 was repeated using 697 mg (3.0 mmol.) of 1-[3-amino-3-(4-methylphenyl)propyl]piperidine and 575 mg (3.0 mmol.) of quinaldinoyl chloride, to obtain 1.09 g (yield: 94%) of the subject compound as a pale yellow oily product.
出典と根拠
- ORDレコード
- ord-e23e5c91e54d441bb93a1d01fb47a7f2
- 出典データセット
- uspto-grants-1988_08