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Acetone → 3-Piperidinopropiophenone hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Acetophenone | HCID 7410 | — |
| 反応物 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-Piperidinopropiophenone hydrochloride | HCID 70171 | 75.4% |
反応手順
A mixture of 120 g of acetophenone, 133 g of piperidine hydrochloride and 50 g of paraformaldehyde in 120 ml of ethanol was refluxed for 6 hours. The mixture was then allowed to stand for cooling to soldify. The resulting solid was crushed after addition of 400 ml of acetone, and then collected by filtration. The collected solid was washed successively with acetone and hexane and dried to obtain 191.6 g (yield: 75.4%) of the subject compound as a white scaly product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764617 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-2a8bdce2894f4e98a5de81fcefcaeafc |
| 出典メモ | uspto-grants-1988_08 |