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Piperidine → Methyl 3-(piperidin-1-ylmethyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Methyl 3-(bromomethyl)benzoate | HCID 517981 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Methyl 3-(piperidin-1-ylmethyl)benzoate | HCID 7162043 | — |
反応手順
A mixture of piperidine (25 ml) and 3-(bromomethyl)benzoic acid, methyl ester (20 g) in toluene (600 ml) was stirred at room temperature for 4 h. The white preciptiate was removed by filtration and the filtrate was distilled to give the title compound as a colourless oil (17.56 g) b.p. 110° (10-1 mm). TLC silica; ether; Rf 0.7.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764612 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-d2db7d61cdb94d9a851edbff15c6518d |
| 出典メモ | uspto-grants-1988_08 |