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Methanesulfonic Acid → 5-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonic Acid | HCID 6395 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-Amino-1-butanol | HCID 25868 | — |
| 反応物 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine | HCID 21297583 | 29.2% |
反応手順
A mixture of methanesulphonic acid (86 g), 5-[(dimethylamino)methyl]-2-furanmethanol (15.5 g) and 4-aminobutanol (17.8 g) in dry tetrahydrofuran was heated at 100° for 11/2 h. Excess sodium carbonate was added to the cooled solution, the suspension was filtered and the filtrate was evaporated to give a red oil which was dissolved in water and extracted with ether. The extract was distilled to give the title compound as an oil (6.6 g) b.p. 100°-110°, 0.08 mm. TLC silica, methanol/ammonia 0.88 80:1, Rf 0.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764612 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c405c788e86d4234a8a437fe7eab9832 |
| 出典メモ | uspto-grants-1988_08 |