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Hydrochloric Acid → HCID 178520398、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetamide, 2-cyano-N-phenyl- | HCID 69296 | — |
| 反応物 | Tributyltin azide | HCID 4984872 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | HCID 178520398 | HCID 178520398 | 90.3% |
反応手順
A solution of 2-cyano-acetanilide (0.801 g, 5.0 mmol) and tri-n-butyltin azide (2.05 mL, 7.5 mmol) in anhydrous toluene (10 mL) was heated at reflux for 48 hrs. The mixture was allowed to cool to room temperature and treated with 2.0 N HCl in Et2O (5.0 mL). The resulting precipate was collected by suction, washed with hexane and dried in vacuo to give 2-(1H-tetrazol-5-yl)acetanilide (0.917 g, 90%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183260B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-c70a5eba16b7425b8003797554719346 |
| 出典メモ | uspto-grants-2007_02 |