Water → 2-Methoxybenzyl isothiocyanate

HRID 350634

反応式

HRID 350634 の反応式
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH2:6].[C:11](Cl)(Cl)=[S:12].O>C(OCC)C>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][N:6]=[C:11]=[S:12]

参加物

5

反応物 3

HCID 962WaterHCID 10040ThiophosgeneHCID 812922-Methoxybenzylamine

生成物 1

HCID 1402562-Methoxybenzyl isothiocyanate収率 99.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 2-methoxybenzylamine (1.80 g) in diethylether (20 ml) was added dropwise under ice-cooling for 10 minutes thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the reaction solution was added water (30 ml), extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxybenzyl)isothiocyanate (2.35 g, yield: 99%) as brown oil.

後処理

  1. extractionextracted with diethylether (60 ml)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ebf9e4bbd5ad47818e77d3b9f31b4e6b
出典データセット
uspto-grants-2007_02
特許番号
US07183275B2

関連ノート

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