3-Benzyloxy-4-methoxypicolinic acid → 3-Hydroxy-4-methoxypyridine-2-carboxylic acid

HRID 350651

反応式

HRID 350651 の反応式
C([O:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1>C(O)C.[C].[Pd]>[OH:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

参加物

4

反応物 1

HCID 199602893-Benzyloxy-4-methoxypicolinic acid

生成物 1

HCID 110411213-Hydroxy-4-methoxypyridine-2-carboxylic acid収率 81.6%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

3-Benzyloxy-4-methoxypicolinic acid (5.3 g) was suspended in 25 ml of ethanol. 10% palladium-carbon (0.5 g) was added to the suspension. The mixture was then catalytically hydrogenated under atmospheric pressure for 30 min. The reaction solution was filtered under the reduced pressure. The filtrate was concentrated under the reduced pressure to give 2.8 g (yield 81.6%) of the title compound as colorless powder.

後処理

  1. filtrationThe reaction solution was filtered under the reduced pressure
  2. concentrationThe filtrate was concentrated under the reduced pressure

出典と根拠

ORDレコード
ord-fdccc608141d4e1c8f6a5004e9b1d6cb
出典データセット
uspto-grants-2007_02
特許番号
US07183278B1

関連ノート

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