Hydrochloric Acid → 3-Hydroxy-4-methoxypicolinic acid hydrochloride

HRID 350652

反応式

HRID 350652 の反応式
C([O:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[ClH:20]>CO>[ClH:20].[OH:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 199602893-Benzyloxy-4-methoxypicolinic acid

生成物 1

HCID 694976023-Hydroxy-4-methoxypicolinic acid hydrochloride収率 54.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Benzyloxy-4-methoxypicolinic acid (8.3 g) was dissolved in 100 ml of methanol. Concentrated hydrochloric acid (2 ml) was added to the solution. The mixture was heated under reflux for 30 min. The reaction solution was concentrated under the reduced pressure. The residue was recrystallized from water-ethanol to give 3.6 g (yield 54.8%) of title compound as colorless powder.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 min
  3. concentrationThe reaction solution was concentrated under the reduced pressure
  4. customThe residue was recrystallized from water-ethanol

出典と根拠

ORDレコード
ord-a78ece4b9afc480db0193fba1d565803
出典データセット
uspto-grants-2007_02
特許番号
US07183278B1

関連ノート

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