HCID 10661075、化合物 → Diethyl P-[(4-aminophenyl)hydroxymethyl]phosphonate

HRID 350720ノート

反応式

HRID 350720 の反応式
[OH:1][CH:2]([P:12](=[O:19])([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][CH:4]=1>[C].[Pd].CO>[NH2:9][C:6]1[CH:5]=[CH:4][C:3]([CH:2]([P:12](=[O:19])([O:13][CH2:14][CH3:15])[O:16][CH2:17][CH3:18])[OH:1])=[CH:8][CH:7]=1

参加物

4

反応物 1

HCID 10661075HCID 10661075、化合物

生成物 1

HCID 23061737Diethyl P-[(4-aminophenyl)hydroxymethyl]phosphonate収率 80.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To a mixed solution of diethyl α-hydroxy-4-nitrobenzylphosphonate (1.42 g) and methanol (30 mL) was added 10% palladium-carbon (0.14 g) and the mixture was stirred at room temperature under an atmospheric hydrogen pressure for 3 hrs. Palladium-carbon was removed from the reaction mixture by filtration and the filtrate was concentrated to give diethyl 4-amino-α-hydroxybenzylphosphonate as a solid (1.02 g, yield 80%).

後処理

  1. customPalladium-carbon was removed from the reaction mixture by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-fac6fbc6f42e4732b1d12a2f954e3d77
出典データセット
uspto-grants-2007_02
特許番号
US07183276B2

反応ノート

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