Acetic Acid → HCID 23061948、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[C-]#[N:13].[K+].C[CH:16]([OH:18])C.C(O)(=O)C>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:13][C:16](=[O:18])[O:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1参加物
6
実験手順
To a mixed solution of 1-(3-chlorophenyl)-2-hydroxyethanone (21.8 g), potassium cyanide (20.8 g) and 2-propanol (100 mL) was added acetic acid (18 mL) at room temperature. After stirring for 30 min, water was added, and the precipitated crystals were collected by filtration and recrystallized from methanol-diisopropyl ether to give 4-(3-chlorophenyl)oxazol-2(3H)-one (6.7 g, yield 41%) as a solid.
後処理
- filtrationthe precipitated crystals were collected by filtration
- customrecrystallized from methanol-diisopropyl ether
出典と根拠
- ORDレコード
- ord-a9e8cc26de6e4b78b32beb6c7e737c38
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07183276B2
反応ノート
読み込み中…