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1-(4-Nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-Aminophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872629 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | 1-(4-Aminophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872634 | — |
反応手順
In a manner analogous to that described in Example 1a, 5.0 g of 1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 250 ml of 2-methoxyethanol are hydrogenated at 45° in the presence of 0.5 g of 5% palladium-on-carbon and worked up. The title compound is obtained which, after recrystallisation from 2-methoxyethanol, melts at 265° with decomposition.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764640 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-ba979a78f059435198692ae5c9f14039 |
| 出典メモ | uspto-grants-1988_08 |