Hydrochloric Acid → 1-(4-(Trifluoromethyl)phenyl)piperidin-4-amine hydrochloride

HRID 350856ノート

反応式

HRID 350856 の反応式
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[ClH:25]>O1CCOCC1>[ClH:25].[F:24][C:2]([F:1])([F:23])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21090462Tert-butyl 1-[4-(trifluoromethyl)phenyl]piperidin-4-ylcarbamate

生成物 1

HCID 210903881-(4-(Trifluoromethyl)phenyl)piperidin-4-amine hydrochloride収率 92%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A round bottom flask was mixed with tert-butyl 1-[4-(trifluoromethyl)phenyl]piperidin-4-ylcarbamate (472 mg, 1.42 mmol) and a solution of 4.0 N HCl in 1,4-dioxane (20 mL). The reaction mixture was allowed to stir at RT for a period of 17.0 hours. After 17.0 hours the reaction mixture was concentrated to dryness to afford a crude solid. The resulting solid was triturated with ether and filtered to give a total of 377 mg of desired product (92% yield). The product was used without further purification.

後処理

  1. concentrationAfter 17.0 hours the reaction mixture was concentrated to dryness
  2. customto afford a crude solid
  3. customThe resulting solid was triturated with ether
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-d5d4a40a36244539bada1e649754e652
出典データセット
uspto-grants-2007_02
特許番号
US07183290B2

反応ノート

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