Potassium Carbonate → 4-((Isopropyl(methyl)amino)methyl)thiazol-2-amine

HRID 350957

反応式

HRID 350957 の反応式
[CH3:1][NH:2][CH:3]([CH3:5])[CH3:4].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH:3]([N:2]([CH2:13][C:11]1[N:12]=[C:8]([NH2:7])[S:9][CH:10]=1)[CH3:1])([CH3:5])[CH3:4]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)HCID 78485N-Methylisopropylamine

生成物 1

HCID 210906044-((Isopropyl(methyl)amino)methyl)thiazol-2-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N-methyl-N-isopropylamine (3.02 g, 41 mmol) is added to a suspension of 2-amino-4-chloromethylthiazole hydrochloride (0.185 g, 1.0 mmol) in 15 mL ethanol. The reaction mixture is allowed to stand at room temperature for 4 days. The mixture was poured into aqueous potassium carbonate. The resulting aqueous suspension is extracted with dichloromethane. The organic layer is dried over MgSO4 and condensed to brown oil.

後処理

  1. extractionThe resulting aqueous suspension is extracted with dichloromethane
  2. dry with materialThe organic layer is dried over MgSO4 and condensed to brown oil

出典と根拠

ORDレコード
ord-c3743e0ec4dd42899e707ab5c78cd1e5
出典データセット
uspto-grants-2007_02
特許番号
US07183300B2

関連ノート

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