Potassium Carbonate → 4-((Isopropyl(methyl)amino)methyl)thiazol-2-amine
反応式
[CH3:1][NH:2][CH:3]([CH3:5])[CH3:4].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH:3]([N:2]([CH2:13][C:11]1[N:12]=[C:8]([NH2:7])[S:9][CH:10]=1)[CH3:1])([CH3:5])[CH3:4]参加物
5
実験手順
N-methyl-N-isopropylamine (3.02 g, 41 mmol) is added to a suspension of 2-amino-4-chloromethylthiazole hydrochloride (0.185 g, 1.0 mmol) in 15 mL ethanol. The reaction mixture is allowed to stand at room temperature for 4 days. The mixture was poured into aqueous potassium carbonate. The resulting aqueous suspension is extracted with dichloromethane. The organic layer is dried over MgSO4 and condensed to brown oil.
後処理
- extractionThe resulting aqueous suspension is extracted with dichloromethane
- dry with materialThe organic layer is dried over MgSO4 and condensed to brown oil
出典と根拠
- ORDレコード
- ord-c3743e0ec4dd42899e707ab5c78cd1e5
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07183300B2
反応ノート
読み込み中…