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2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+/-)-2-[4-({[2-(Benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid | HCID 2736879 | — |
| 反応物 | Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate | HCID 18174008 | — |
| 反応物 | 2-(2,1,3-Benzoxadiazol-5-yloxy)nicotinic acid | HCID 22610138 | — |
| 反応物 | (+)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester | HCID 23529364 | — |
| 生成物 | (+/-)-2-[4-({[2-(Benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester | HCID 23529359 | — |
反応手順
The compound of Formula (5.0.23) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(benzo[2,1,3]oxadiazol-5-yloxy)-nicotinic acid and (+)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183293B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-be25ae5e32cb4ed597a01e2edd405010 |
| 出典メモ | uspto-grants-2007_02 |