2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+/-)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester

HRID 350984

反応式

HRID 350984 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[N:19]=[CH:18][C:17]([F:20])=[CH:16][C:12]=3[C:13]([OH:15])=O)=[CH:9][C:4]=2[O:3][CH2:2]1.[C:21]([O:25][C:26](=[O:39])[CH:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][NH2:37])=[C:32]([F:38])[CH:31]=1)[CH3:28])([CH3:24])([CH3:23])[CH3:22].O1C2C=CC(OC3N=CC=CC=3C(O)=O)=CC=2OC1.COC(=O)COC1C=CC(CN)=C(F)C=1>>[C:21]([O:25][C:26](=[O:39])[CH:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][NH:37][C:13]([C:12]2[C:11]([O:10][C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)=[N:19][CH:18]=[C:17]([F:20])[CH:16]=2)=[O:15])=[C:32]([F:38])[CH:31]=1)[CH3:28])([CH3:22])([CH3:23])[CH3:24]

参加物

5

反応物 4

HCID 27368792-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acidHCID 18174008Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetateHCID 220584122-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-nicotinic acidHCID 23529364(+)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester

生成物 1

HCID 23529362(+/-)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester

実験手順

The compound of Formula (5.0.26) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(benzo[1,3]dioxol-5-yloxy)-5-fluoro-nicotinic acid and (±)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.

後処理

  1. customthat described in Preparation 20

出典と根拠

ORDレコード
ord-567e80e7a73a4fcea174dc80c0860940
出典データセット
uspto-grants-2007_02
特許番号
US07183293B2

関連ノート

読み込み中…