2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (R)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid methyl ester

HRID 350987

反応式

HRID 350987 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[O:6][C:7]1[N:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=O)#[N:2].[CH3:19][O:20][C:21](=[O:34])[C@H:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][NH2:32])=[C:27]([F:33])[CH:26]=1)[CH3:23].O1C2C=CC(OC3N=CC=CC=3C(O)=O)=CC=2OC1.COC(=O)COC1C=CC(CN)=C(F)C=1>>[CH3:19][O:20][C:21](=[O:34])[C@H:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][NH:32][C:9]([C:8]2[C:7]([O:6][C:5]3[CH:16]=[CH:17][CH:18]=[C:3]([C:1]#[N:2])[CH:4]=3)=[N:15][CH:14]=[CH:13][CH:12]=2)=[O:11])=[C:27]([F:33])[CH:26]=1)[CH3:23]

参加物

5

反応物 4

HCID 27368792-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acidHCID 128493352-(3-Cyano-phenoxy)-nicotinic acidHCID 18174008Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetateHCID 60128049(R)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid methyl ester

生成物 1

HCID 60128044(R)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid methyl ester

実験手順

The compound of Formula (5.0.31) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(3-cyano-phenoxy)-nicotinic acid and (R)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid methyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.

後処理

  1. customthat described in Preparation 20

出典と根拠

ORDレコード
ord-fb4a9e92b20d4e6e90d39bb2378bfa81
出典データセット
uspto-grants-2007_02
特許番号
US07183293B2

関連ノート

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