(+/-)-2-[4-({[2-(Benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester → (+/-)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid

反応式

C([O:5][C:6](=[O:36])[CH:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]([C:20]2[C:21]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=3)=[N:22][CH:23]=[CH:24][CH:25]=2)=[O:19])=[C:12]([F:35])[CH:11]=1)[CH3:8])(C)(C)C.C(OC(=O)C(OC1C=CC(CNC(C2C(OC3C=CC4=NON=C4C=3)=NC=CC=2)=O)=C(F)C=1)C)(C)(C)C>>[F:35][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][C:13]=1[CH2:16][NH:17][C:18]([C:20]1[C:21]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=2)=[N:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[O:9][CH:7]([CH3:8])[C:6]([OH:36])=[O:5]

参加物

反応物 2

HCID 23529359(+/-)-2-[4-({[2-(Benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester

HCID 23529361(+)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid tert-butyl ester

生成物 1

HCID 10274614(+/-)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid

実験手順

The compound of Formula (5.5.5) was prepared in a manner analogous to described in Example 3, substituting (+)-2-[3-fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid tert-butyl ester for the corresponding (±)-2-[4-({[2-(benzo[2,1,3]oxadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester material.

出典と根拠

ORDレコード: ord-e215e12d570743a2ab9cc2b0904110d2
出典データセット: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07183293B2

反応ノート

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