Dichloromethane → 3-[3-(Naphthalen-1-ylsulfamoyl)phenyl]-acryloyl Chloride

HRID 351059ノート

反応式

HRID 351059 の反応式
[C:1]1([NH:11][S:12]([C:15]2[CH:16]=[C:17]([CH:21]=[CH:22][C:23]([OH:25])=O)[CH:18]=[CH:19][CH:20]=2)(=[O:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:26]CCl>CN(C)C=O>[C:1]1([NH:11][S:12]([C:15]2[CH:16]=[C:17]([CH:21]=[CH:22][C:23]([Cl:26])=[O:25])[CH:18]=[CH:19][CH:20]=2)(=[O:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 670195673-[3-(Naphthalen-1-ylsulfamoyl)-phenyl]-acrylic acid

生成物 1

HCID 739894023-[3-(Naphthalen-1-ylsulfamoyl)phenyl]-acryloyl Chloride収率 99.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

反応条件

温度
40 °C

実験手順

To a suspension of 3-[3-(naphthalen-1-ylsulfamoyl)-phenyl]-acrylic acid (15d) (0.22 g, 0.62 mmol) in dichloromethane (2.5 ml) oxalyl chloride (0.16 ml, 1.86 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.23 g, 99%).

後処理

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-eb5776f0e77a4c51a1705fb109988248
出典データセット
uspto-grants-2007_02
特許番号
US07183298B2

反応ノート

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