Methanol → 3-{3-[(Benzo[1,3]dioxol-5-ylmethyl)sulfamoyl]-phenyl}-acrylic acid

HRID 351097ノート

反応式

HRID 351097 の反応式
C[O:2][C:3](=[O:26])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12](=[O:25])(=[O:24])[NH:13][CH2:14][C:15]2[CH:23]=[CH:22][C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=2)[CH:7]=1.CO>>[O:19]1[C:18]2[CH:22]=[CH:23][C:15]([CH2:14][NH:13][S:12]([C:8]3[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:26])=[O:2])[CH:11]=[CH:10][CH:9]=3)(=[O:25])=[O:24])=[CH:16][C:17]=2[O:21][CH2:20]1

参加物

3

反応物 2

HCID 887MethanolHCID 670196013-{3-[(Benzo[1,3]dioxol-5-ylmethyl)-sulfamoyl]-phenyl}acrylic Acid Methyl Ester

生成物 1

HCID 670195213-{3-[(Benzo[1,3]dioxol-5-ylmethyl)sulfamoyl]-phenyl}-acrylic acid

実験手順

To a suspension of 3-{3-[(benzo[1,3]dioxol-5-ylmethyl)-sulfamoyl]-phenyl}-acrylic acid methyl ester (0.47 g, 1.25 mmol) in methanol (6 ml) 1N NaOH solution (3.75 ml, 3.75 mmol) was added and the resultant mixture was stirred at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 2N HCl solution and stirred for 30 min. The precipitated solid was filtered, washed with water and dried in desiccator over P2O5. The title compound was obtained as a white solid (0.39 g, 87%).

後処理

  1. additionwas added
  2. customThe reaction mixture was partitioned between ethyl acetate and water
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. dry with materialdried in desiccator over P2O5

出典と根拠

ORDレコード
ord-3cbfbcbc2b5f4d32b52c75f01d5feff0
出典データセット
uspto-grants-2007_02
特許番号
US07183298B2

反応ノート

読み込み中…