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4-tert-Butylcyclohexylamine → N-(4-tert-Butylcyclohexyl)-N'-(7-hydroxynaphthalen-1-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-tert-Butylcyclohexylamine | HCID 79396 | — |
| 反応物 | (7-Hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester | HCID 20090380 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | N-(4-tert-Butylcyclohexyl)-N'-(7-hydroxynaphthalen-1-yl)urea | HCID 18435880 | — |
反応手順
4-tert-Butyl-cyclohexylamine (69 mg, 0.44 mmol) and (7-hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester (125 mg, 0.44 mmol) were combined and stirred at ambient temperature in DMSO (3 mL) overnight. The product was purified by directly injecting the crude reaction onto a reverse phase prep-HPLC (90–10% water:acetonitrile gradient). The appropriate fractions were lyophilized to yield 1-(4-tert-Butyl-cyclohexyl)-3-(7-hydroxy-naphthalen-1-yl)-urea
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183411B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-75db14825a1f48a6961e36069b97b72c |
| 出典メモ | uspto-grants-2007_02 |