関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,2,2-Trifluoroacetophenone | HCID 9905 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | l-Valine, ethyl ester | HCID 87182 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-(2,2,2-Trifluoro-1-phenylethylidene)-L-valine potassium salt | HCID 58599713 | — |
反応手順
2,2,2-Trifluoroacetophenone (4.24 g, 24.3 mmol) was added to a mixture of L-valine ethyl ester (3.21 g, 22.1 mmol) and K2CO3 (2.90 g, 20.9 mmol) in MeOH (50 mL). The mixture was warmed to 50° C. for 18 h. The mixture was cooled to 20–25° C., filtered and concentrated. The residue was suspended in TBME (100 ml) and filtered to give the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07183425B2 |
|---|
| 出典データセット | uspto-grants-2007_02 |
|---|
| ORD ID | ord-9b16be21d1324a09bd32db5352ab2673 |
|---|
| 出典メモ | uspto-grants-2007_02 |
|---|
