Ethanol → HCID 23022412、化合物

HRID 351347

反応式

HRID 351347 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][F:6].[F:7][C:8]1[CH:16]=[C:15]([OH:17])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11].C(O)C.[OH-].[K+]>O>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH2:2][CH2:3][CH2:4][CH2:5][F:6])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11]

参加物

6

反応物 4

HCID 702EthanolHCID 100221-Bromo-4-fluorobutaneHCID 14797Potassium HydroxideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

生成物 1

HCID 23022412HCID 23022412、化合物収率 39.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

1-Bromo-4-fluorobutane (3.57 g, 23.1 mmol) was added dropwise to a mixture of 2-fluoro-4-hydroxybenzoic acid (3.00 g, 19.2 mmol), ethanol (11.5 ml) and water (2.3 ml), potassium hydroxide (2.37 g, 42.3 mmol) at 80° C., and the mixture was stirred at 80° C. for 17 hrs. The solvent was evaporated under reduced pressure. The residue was dissolved in water and the solution was acidified by adding 1N hydrochloric acid. The insoluble materials were filtered off and dried to give the title compound (1.73 g) as a pale-brown powder.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. additionby adding 1N hydrochloric acid
  4. filtrationThe insoluble materials were filtered off
  5. customdried

出典と根拠

ORDレコード
ord-a90d447d5d524a98a661fb371990aede
出典データセット
uspto-grants-2007_02
特許番号
US07183415B2

関連ノート

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