化工社化工社 化学情報印刷レポート · 研究参考用
Water → O-Terphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Neopentyl glycol | HCID 31344 | — |
| 反応物 | (4-Propylphenyl)boronic acid | HCID 4100861 | — |
| 反応物 | Trimethyl(2,3,2'-trifluoro-4'-iodobiphenyl-4-yl)silane | HCID 11304300 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | O-Terphenyl | HCID 6766 | 89% |
反応手順
A solution of (2 mmol) of 8, (2.2 mmol) of 4-propylphenylboronic acid, 250 mg (2.40 mmol) of neopentyl glycol, 1.53 g (4.84 mmol) of Ba(OH)2. 8 H2O, 1.35 ml (0.103 mmol, 5 mol %) of a 76 mM acetone solution of Pd(OAc)2 in 20 ml of 95% i-PrOH is stirred at 80° C. for 12 hours. The solvent is subsequently removed under reduced pressure. 5 ml of 2 M HCl are added to the residue, and the mixture is extracted with dichloromethane (3×5 ml). The combined organic phases are dried over MgSO4 and filtered through SiO2. The solvent is removed under reduced pressure, and the residue is converted into 10 (yield: 89%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183447B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-0af43673288f46c383c67af9db9d4a47 |
| 出典メモ | uspto-grants-2007_02 |