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Boron trifluoride → 4-(4-Benzyloxy-phenyl)-1-methyl-cyclohex-3-ene carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride | HCID 6356 | — |
| 反応物 | Methacrolein | HCID 6562 | — |
| 反応物 | 1-(Benzyloxy)-4-(buta-1,3-dien-2-yl)benzene | HCID 18436327 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(4-Benzyloxy-phenyl)-1-methyl-cyclohex-3-ene carbaldehyde | HCID 86595845 | — |
反応手順
1-benzyloxy-4-(1-methylene-allyl)-benzene (0.40 g, 1.694 mmol) and 2-methyl-propenal (0.355 mL) in DCM (10 mL) was cooled to −10° C. BF3.OCH2CH3 (0.322 mL, 1.778 mmol) was added and the reaction mixture stirred for 3 h. The mixture was then quenched by aqueous saturated NaHCO3 solution. After extraction with ethyl acetate (2×100 mL), the reaction mixture was dried over MgSO4 and purified on SiO2 to yield 4-(4-benzyloxy-phenyl)-1-methyl-cyclohex-3-ene carbaldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183445B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-04161045a5294dad8b51e523f70816bd |
| 出典メモ | uspto-grants-2007_02 |