関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Hydroxybenzonitrile | HCID 11907 | — |
| 反応物 | Diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate | HCID 23037018 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate | HCID 21295006 | 86% |
反応手順
11.9 g of cyano-phenol and 32.6 g of diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate are dissolved in 150 ml of dimethyl sulfoxide, whereupon 13.8 g of potassium carbonate are added and the reaction mixture is stirred at 60° C. for 6 hours. The reaction mixture is filtered and the filtrate is evaporated. Thus 36 g of the desired compound are obtained, yield 86%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04765825 |
|---|
| 出典データセット | uspto-grants-1988_08 |
|---|
| ORD ID | ord-39eba38794a340b28f97b842753e7fc2 |
|---|
| 出典メモ | uspto-grants-1988_08 |
|---|
