化工社化工社 化学情報印刷レポート · 研究参考用
Acetamidomalonic acid diethyl ester → Diethyl 2-acetamido-2-(diphenylmethyl)malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| 反応物 | Bromodiphenylmethane | HCID 236603 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Diethyl 2-acetamido-2-(diphenylmethyl)malonate | HCID 14211495 | — |
反応手順
Dissolve sodium (2 g) in 400 ml ethanol and add diethyl acetamidomalonate (10.4 g). Stir 5 minutes, add diphenyl bromomethane (12.4 g), and stir 7 hours at room temperature. Acidify the reaction mixture, partition between water and methylene chloride (CH2Cl2), dry the organic layer over magnesium sulfate (MgSO4), filter, and evaporate the solvent to obtain the crude title compound as a pale yellow oil. Rf (silica gel; Et2O)=0.89.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766109 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-18b2b873df424d9bacf447d4ae203cba |
| 出典メモ | uspto-grants-1988_08 |